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This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated. There are no data with Augmentin and allopurinol administered concurrently. The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. The total amount of allopurinol is usually not more than 800 mg a day. Keep Allopurinol out of the reach of children and away from pets.
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