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Triamterene, one of the ingredients of Dyazide, helps to minimize the potassium loss that can be caused by the other component, hydrochlorothiazide. Hyperkalemia may complicate any of the following conditions: chronic renal failure, systemic acidosis, such as diabetic acidosis, acute dehydration, extensive tissue breakdown as in severe burns, adrenal insufficiency, or the administration of a potassium-sparing diuretic (eg, spironolactone, triamterene, amiloride) (see OVERDOSAGE). {51} {52} Amiloride and triamterene have a direct inhibitory effect on the entry of sodium into the cells, while spironolactone competitively inhibits the action of aldosterone. htmlTriamterene is generally well-tolerated, especially in patients with adequate urine output. , spironolactone, triamterene, or amiloride), since the simultaneous administration of these agents can produce severe hyperkalemia.

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